Decoding the Physical Code of Living Matter via Dynamic Force Spectroscopy

by Prof. Ching-Hwa Kiang (Department of Physics & Astronomy, Rice University)

Wednesday 15 Apr 2026, 13:30 → 15:30 Asia/Taipei

L124, Physics Building (NTHU)

Measuring the physical properties of complex, out-of-equilibrium biological systems requires precise nanoscale investigation. At this scale, living matter is governed by rugged energy landscapes that dictate both form and function. Recent advancements in single-molecule and single-cell dynamic force spectroscopy provide a powerful means to decode this underlying mechanical language. Utilizing atomic force microscopy (AFM), we developed a novel, label-free method to characterize both biomolecular dynamics and cellular states through their unique mechanical and acoustic signatures. By analyzing the force responses of diverse systems, including DNA, multimeric proteins, graphene nanoribbons, and mammalian cells, the thermodynamics of living matter can be directly observed in action. Ultimately, establishing these nanoscale mechanical signatures provides a crucial framework for addressing complex scientific and medical challenges, such as protein folding mechanics and advanced cancer diagnosis.